Signaling pathways and polyomavirus oncoproteins: Importance in malignant transformation
نویسندگان
چکیده
*Correspondence: Dr. Martyn K. White, Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Bio-Life Sciences Building, Room 238, 1900 North 12th Street, MS 015-96, Philadelphia, PA 19122; Tel: 215-204-0620; Fax: 215-204-0679; Email: [email protected]
منابع مشابه
Interaction of viral oncogenic proteins with the Wnt signaling pathway
It is estimated that up to 20% of all types of human cancers worldwide are attributed to viruses. The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation. The modulation of cell cycle control mechanisms, cellular regulatory and signaling pathways by oncogenic viruses, plays an important role in viral carcinogenes...
متن کاملDifferent susceptibility of human mesothelial cells to polyomavirus infection and malignant transformation.
SV40 has been associated with mesothelioma development. The possible role of the closely related human polyomaviruses JC virus (JCV) and BK virus (BKV) in mesothelioma remained unclear. We found that JCV did not infect human mesothelial cells. BKV and SV40 infected mesothelial cells, expressed viral oncoproteins, and caused similar alterations of key cell regulatory genes. BKV replicated faster...
متن کاملPhosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation.
Phosphatidylinositol-3 kinase (PI3K) is one of the most important regulatory proteins that is involved in different signaling pathways and controlling of key functions of the cell. The double-enzymatic activity of PI3K (lipid kinase and protein kinase) as well as the ability of this enzyme to activate a number of signal proteins including some oncoproteins determines its fundamental significanc...
متن کاملVirocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways.
This review describes a mechanism of viral transformation involving activation of cellular signaling pathways. We focus on four viral oncoproteins: the E5 protein of bovine papillomavirus, which activates the platelet-derived growth factor beta receptor; gp55 of spleen focus forming virus, which activates the erythropoietin receptor; polyoma virus middle T antigen, which resembles an activated ...
متن کاملConstitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.
Signal transducers and activators of transcription (STATs) were originally identified as key components of signaling pathways involved in mediating responses to IFNs. Previous studies showed that the Src oncoprotein constitutively activates one STAT family member, Stat3. In this study, we investigated STAT activation in a panel of rodent fibroblast cell lines stably transformed by diverse viral...
متن کامل